Browsing by Author "Lai, Meng-Chuan"

Now showing items 1-15 of 15

    • Article  

      Are power calculations useful? A multicentre neuroimaging study 

      Suckling, John; Henty, Julian; Ecker, C.; Deoni, Sean C. L.; Lombardo, Michael V.; Baron-Cohen, Simon; Jezzard, Peter; Barnes, Anna; Chakrabarti, B.; Ooi, Cinly; Lai, Meng-Chuan; Williams, Steven C. R.; Murphy, Declan G. M.; Bullmore, Edward T. (2014)
      There are now many reports of imaging experiments with small cohorts of typical participants that precede large-scale, often multicentre studies of psychiatric and neurological disorders. Data from these calibration ...
    • Article  

      Association between the probability of autism spectrum disorder and normative sex-related phenotypic diversity in brain structure 

      Ecker, C.; Andrews, Derek Sayre; Gudbrandsen, Christina M.; Marquand, Andre F.; Ginestet, Cedric E.; Daly, Eileen M.; Murphy, Clodagh M.; Lai, Meng-Chuan; Lombardo, Michael V.; Ruigrok, Amber N. V.; Bullmore, Edward T.; Suckling, John; Williams, Steven C. R.; Baron-Cohen, Simon; Craig, Michael C.; Murphy, Declan G. M. (2017)
      IMPORTANCE Autism spectrum disorder (ASD) is 2 to 5 times more common in male individuals than in female individuals. While the male preponderant prevalence of ASD might partially be explained by sex differences in clinical ...
    • Article  

      Autism attenuates sex differences in brain structure: A combined voxel-based morphometry and diffusion tensor imaging study 

      Beacher, Felix D. C. C.; Minati, L.; Baron-Cohen, Simon; Lombardo, Michael V.; Lai, Meng-Chuan; Gray, Marcus A.; Harrison, Neil A.; Critchley, Hugo D. (2012)
      BACKGROUND AND PURPOSE: It has been proposed that autism spectrums condition may represent a form of extreme male brain (EMB), a notion supported by psychometric, behavioral, and endocrine evidence. Yet, limited data are ...
    • Article  

      Big data approaches to decomposing heterogeneity across the autism spectrum 

      Lombardo, Michael V.; Lai, Meng-Chuan; Baron-Cohen, Simon (2019)
      Autism is a diagnostic label based on behavior. While the diagnostic criteria attempt to maximize clinical consensus, it also masks a wide degree of heterogeneity between and within individuals at multiple levels of analysis. ...
    • Article  

      Decreased centrality of cortical volume covariance networks in autism spectrum disorders 

      Balardin, J. B.; Comfort, W. E.; Daly, Eileen M.; Murphy, Clodagh M.; Andrews, Derek Sayre; Murphy, Declan G. M.; Ecker, C.; Sato, J. R.; Bailey, Anthony J.; Baron-Cohen, Simon; Bolton, P. F.; Bullmore, Edward T.; Carrington, S.; Catani, Marco; Chakrabarti, B.; Craig, Michael C.; Daly, Eileen M.; Deoni, Sean C. L.; Happé, Francesca; Henty, Julian; Jezzard, Peter; Johnston, Patrick; Jones, D. K.; Lai, Meng-Chuan; Lombardo, Michael V.; Madden, A.; Mullins, D.; Murphy, Clodagh M.; Murphy, Declan G. M.; Pasco, Greg; Ruigrok, Amber N. V.; Sadek, Susan A.; Spain, D.; Stewart, R.; Suckling, John; Wheelwright, Sally J.; Williams, Steven C. R.; Wilson, C. E.; MRC AIMS Consortium (2015)
      Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by atypical structural and functional brain connectivity. Complex network analysis has been mainly used to describe altered ...
    • Article  

      EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort 

      Isaksson, Johan; Tammimies, Kristiina; Neufeld, Janina; Cauvet, Élodie; Lundin, Karl; Buitelaar, Jan K.; Loth, Eva; Murphy, Declan G. M.; Spooren, Will; Bölte, Sven; Ahmad, Jumana; Ambrosino, Sara; Auyeung, Bonnie; Banaschewski, Tobias; Baron-Cohen, Simon; Baumeister, Sarah; Beckmann, Christian; Bourgeron, Thomas; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; de Bruijn, Yvette; Chakrabarti, Bhismadev; Charman, Tony; Crawley, Daisy; Cornelissen, Ineke; Dell’ Acqua, Flavio; Dumas, Guillaume; Durston, Sarah; Ecker, Christine; Frouin, Vincent; Garcés, Pilar; Goyard, David; Ham, Lindsay; Hayward, Hannah; Hipp, Joerg; Holt, Rosemary J.; Johnson, Mark H.; Jones, Emily J. H.; Kundu, Prantik; Lai, Meng-Chuan; D’ardhuy, Xavier Liogier; Lombardo, Michael; Lythgoe, David J.; Mandl, René; Mason, Luke; Meyer-Lindenberg, Andreas; Moessnang, Carolin; Mueller, Nico; O’Dwyer, Laurence; Oldehinkel, Marianne; Oranje, Bob; Pandina, Gahan; Persico, Antonio M.; Ruggeri, Barbara; Ruigrok, Amber; Sabet, Jessica; Sacco, Roberto; Cáceres, Antonia San José; Simonoff, Emily; Tillmann, Julian; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams, Steve C. R.; Wooldridge, Caroline; Zwiers, Marcel P.; the EU-AIMS LEAP group (2018)
      EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) ...
    • Article  

      In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder 

      Andrews, Derek Sayre; Avino, Thomas A.; Gudbrandsen, Maria; Daly, Eileen M.; Marquand, Andre F.; Murphy, Clodagh M.; Lai, Meng-Chuan; Lombardo, Michael V.; Ruigrok, Amber N. V.; Williams, Steven C. R.; Bullmore, Edward T.; Suckling, John; Baron-Cohen, Simon; Craig, Michael C.; Murphy, Declan G. M.; Ecker, Christine (2017)
      Atypical cortical organization and reduced integrity of the gray-white matter boundary have been reported by postmortem studies in individuals with autism spectrum disorder (ASD). However, there are no in vivo studies that ...
    • Article  

      Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women 

      Bethlehem, R. A. I.; Lombardo, Michael V.; Lai, Meng-Chuan; Auyeung, Bonnie; Crockford, S. K.; Deakin, J. B.; Soubramanian, S.; Sule, A.; Kundu, Prantik; Voon, Valerie; Baron-Cohen, Simon (2017)
      Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male biased and often constrained by task-based inferences. Here, we investigate ...
    • Article  

      A Machine Learning Approach to Reveal the NeuroPhenotypes of Autisms 

      Górriz, Juan M.; Ramírez, Javier; Segovia, F.; Martínez, Francisco J.; Lai, Meng-Chuan; Lombardo, Michael V.; Baron-Cohen, Simon; MRC AIMS Consortium; Suckling, John (2019)
      Although much research has been undertaken, the spatial patterns, developmental course, and sexual dimorphism of brain structure associated with autism remains enigmatic. One of the difficulties in investigating differences ...
    • Article  

      A meta-analysis of sex differences in human brain structure 

      Ruigrok, Amber N. V.; Salimi-Khorshidi, G.; Lai, Meng-Chuan; Baron-Cohen, Simon; Lombardo, Michael V.; Tait, Roger J.; Suckling, John (2014)
      The prevalence, age of onset, and symptomatology of many neuropsychiatric conditions differ between males and females. To understand the causes and consequences of sex differences it is important to establish where they ...
    • Article  

      Neural self-representation in autistic women and association with ‘compensatory camouflaging’: 

      Lai, Meng-Chuan; Lombardo, Michael V.; Chakrabarti, Bhismadev; Ruigrok, Amber NV; Bullmore, Edward T.; Suckling, John; Auyeung, Bonnie; Happé, Francesca; Szatmari, Peter; Baron-Cohen, Simon (2019)
      Prior work has revealed sex/gender-dependent autistic characteristics across behavioural and neural/biological domains. It remains unclear whether and how neura...
    • Article  

      The "reading the mind in the eyes" test: Complete absence of typical sex difference in 400 men and women with autism 

      Baron-Cohen, Simon; Bowen, Daniel C.; Holt, R. J.; Allison, Carrie; Auyeung, Bonnie; Lombardo, Michael V.; Smith, P.; Lai, Meng-Chuan (2015)
      The "Reading the Mind in the Eyes" test (Eyes test) is an advanced test of theory of mind. Typical sex difference has been reported (i.e., female advantage). Individuals with autism show more difficulty than do typically ...
    • Article  

      Sex differences and Autism: Brain function during verbal fluency and mental rotation 

      Beacher, Felix D. C. C.; Radulescu, Eugenia; Minati, L.; Baron-Cohen, Simon; Lombardo, Michael V.; Lai, Meng-Chuan; Walker, Anne; Howard, Dawn; Gray, Marcus A.; Harrison, Neil A.; Critchley, Hugo D. (2012)
      Autism spectrum conditions (ASC) affect more males than females. This suggests that the neurobiology of autism: 1) may overlap with mechanisms underlying typical sex-differentiation or 2) alternately reflect sex-specificity ...
    • Article  

      Sex-specific impact of prenatal androgens on social brain default mode subsystems 

      Lombardo, Michael V.; Auyeung, Bonnie; Pramparo, Tiziano; Courraud, Jérémie; Holt, Rosemary J.; Waldman, Jack; Ruigrok, Amber N. V.; Mooney, Natasha; Bethlehem, Richard A. I.; Lai, Meng-Chuan; Kundu, Prantik; Bullmore, Edward T.; Mandel, Jean-Louis; Piton, Amélie; Baron-Cohen, Simon; Quartier, Angélique (2018)
      Early-onset neurodevelopmental conditions (e.g., autism) affect males more frequently than females. Androgens may play a role in this male-bias by sex-differentially impacting early prenatal brain development, particularly ...
    • Article  

      Subgrouping the Autism "Spectrum": Reflections on DSM-5 

      Lai, Meng-Chuan; Lombardo, Michael V.; Chakrabarti, B.; Baron-Cohen, Simon (2013)